Shunts with blood-flow indicators

ABSTRACT

An apparatus for shunting blood includes a flow-indication chamber shaped to define an entry port and an exit port, and one or more moveable objects disposed within the flow-indication chamber and configured to move in response to a flowing of the blood from the entry port to the exit port. At least a portion of a wall of the flow-indication chamber is transparent so as to expose the moveable objects to sight. Other embodiments are also described.

CROSS-REFERENCE TO RELATED APPLICATIONS

The present application is a continuation of U.S. patent applicationSer. No. 17/576,953, filed Jan. 16, 2022, which claims the benefit ofU.S. Provisional Application 63/138,451, entitled “Visualization ofblood flow in a venous/arterial shunting system,” filed Jan. 17, 2021,whose disclosure is incorporated herein by reference.

FIELD OF THE INVENTION

The present invention relates to medical procedures, such as proceduresin which blood of a subject is shunted from one blood vessel to another.

BACKGROUND

In some procedures, blood is shunted from one blood vessel to another.

SUMMARY OF THE INVENTION

There is provided, in accordance with some embodiments of the presentinvention, an apparatus for shunting blood. The apparatus includes aflow-indication chamber shaped to define an entry port and an exit port,and one or more moveable objects disposed within the flow-indicationchamber and configured to move in response to a flowing of the bloodfrom the entry port to the exit port. At least a portion of a wall ofthe flow-indication chamber is transparent so as to expose the moveableobjects to sight.

In some embodiments, the moveable objects include a plurality of beads.

In some embodiments, at least one of the beads includes multiple faces.

In some embodiments, each of the beads is coated with an anticoagulant.

In some embodiments, the moveable objects include a rotational memberconfigured to rotate in response to the blood exerting a force on therotational member.

In some embodiments, the rotational member includes a wheel including aplurality of spokes.

In some embodiments, the wheel is positioned relative to the entry portand exit port such that each of the spokes, when perpendicular to anunimpeded path of the blood from the entry port to the exit port,intersects the unimpeded path.

In some embodiments, a most proximal point on each of the spokes thatintersects the unimpeded path is located between 50% and 80% of a lengthof the spoke from a proximal end of the spoke.

In some embodiments, the apparatus further includes a filter chamberconfigured to couple to the flow-indication chamber and to hold a bloodfilter in the filter chamber.

In some embodiments, the apparatus further includes a threaded ring,

-   -   the filter chamber is shaped to define a filter-chamber port,    -   the flow-indication chamber is configured to screw into a first        side of the threaded ring, and    -   the filter chamber is configured to screw into a second side of        the threaded ring such that the entry port or exit port is        fluidly connected with the filter-chamber port.

In some embodiments, the flow-indication chamber is further configuredto hold a blood filter therein.

In some embodiments, the apparatus further includes a valve configuredto regulate the flowing of the blood through a port selected from thegroup of ports consisting of: the entry port, and the exit port.

In some embodiments, the valve includes:

-   -   a pushable element passing through a wall of the flow-indication        chamber and configured to cover the port upon being pushed into        the flow-indication chamber; and    -   a spring coupled to the pushable element and to an inner wall of        the flow-indication chamber, and configured to inhibit the        pushable element from covering the port in an absence of any        pushing force applied to the pushable element.

In some embodiments, the spring includes a tension spring.

There is further provided, in accordance with some embodiments of thepresent invention, a method including coupling an upstream end of afirst conduit to a source blood vessel of a subject and a downstream endof the first conduit to an entry port of a shunt. The method furtherincludes coupling an upstream end of a second conduit to an exit port ofthe shunt and a downstream end of the second conduit to a sink bloodvessel of the subject, such that blood flows from the source bloodvessel to the sink blood vessel via the shunt, thus causing movement ofone or more moveable objects disposed within the shunt, the movementbeing visible through a wall of the shunt.

In some embodiments, the shunt includes a flow-indication chamber, whichcontains the moveable objects, and a filter chamber, which is coupled tothe flow-indication chamber and holds a blood filter in the filterchamber.

There is further provided, in accordance with some embodiments of thepresent invention, an apparatus including a chamber shaped to define afluid port, a first appendage protruding from the chamber and shaped todefine a first aperture and a first row of one or more teeth, and asecond appendage protruding from the chamber and shaped to define asecond aperture and a second row of one or more teeth parallel to thefirst row of teeth. The second row is configured to interlock with thefirst row at multiple different relative positions of the firstappendage and second appendage in which the second aperture is alignedwith the first aperture with different respective degrees of alignmentsuch that a tube, which carries blood to or from the fluid port throughthe first aperture and second aperture, is constricted with differentrespective degrees of constriction.

In some embodiments, the chamber is configured to hold a blood filtertherein.

In some embodiments, the apparatus further includes one or more moveableobjects disposed within the chamber and configured to move in responseto a flowing of the blood through the chamber, at least a portion of awall of the chamber being transparent so as to expose the moveableobjects to sight.

In some embodiments, the first appendage and second appendage arecontinuous with a wall of the chamber.

In some embodiments, the first appendage and second appendage areconfigured to revert to a default relative position, in which the tubeis not constricted, upon a release of the first row and second row fromone another.

In some embodiments,

-   -   the first appendage includes a first back arm, which protrudes        from the chamber, and a first front arm, which is angled with        respect to the first back arm and is shaped to define the first        aperture and the first row of teeth, and    -   the second appendage includes a second back arm, which protrudes        from the chamber, and a second front arm, which is angled with        respect to the second back arm and is shaped to define the        second aperture and the second row of teeth.

In some embodiments, each of the teeth in the first row and in thesecond row is angled backward, such that an advancement of the first rowand second row relative to one another constricts the tube.

In some embodiments, the tube is not completely constricted in any ofthe positions.

There is further provided, in accordance with some embodiments of thepresent invention, a method including sliding a first appendage, whichprotrudes from a chamber and is shaped to define a first aperture and afirst row of one or more teeth, across a second appendage, whichprotrudes from the chamber and is shaped to define a second aperture anda second row of one or more teeth parallel to the first row of teeth,such that the second row interlocks with the first row at a relativeposition of the first appendage and second appendage in which the secondaperture is misaligned with the first aperture, thereby constricting atube that carries blood to or from a fluid port of the chamber throughthe first aperture and second aperture. The method further includes,subsequently to constricting the tube, releasing the first row andsecond row from one another, thereby causing the first appendage andsecond appendage to revert to a default relative position in which thetube is not constricted.

The present invention will be more fully understood from the followingdetailed description of embodiments thereof, taken together with thedrawings, in which:

BRIEF DESCRIPTION OF THE DRAWINGS

FIGS. 1-3 are schematic illustrations of an apparatus for shuntingblood, in accordance with some embodiments of the present invention; and

FIGS. 4A-B are schematic illustrations of a tube constrictor, inaccordance with some embodiments of the present invention.

DETAILED DESCRIPTION OF EMBODIMENTS Overview

In some cases, it may be necessary to shunt blood from one anatomicalsite to another. For example, during an operation to remove a clot froma carotid artery of a subject, it may be necessary to shunt blood fromthe carotid artery to a vein, such as a femoral vein, of the subject. Insuch cases, a shunting device (or “shunt”) is used to carry bloodbetween the sites. However, there is a risk of the blood flow throughthe shunt slowing or stopping without the physician noticing.

To mitigate this risk, embodiments of the present invention provide ashunt comprising a flow-indication chamber containing one or moremovable objects, which are configured to move in response to the flow ofblood through the flow-indication chamber. At least a portion of thewall of the flow-indication chamber is transparent, such that themoveable objects are visible. For example, the wall may comprise atransparent window, and the moveable objects may be disposed behind thewindow. Thus, a physician may readily check whether the blood is flowingproperly through the shunt, by observing the degree of motion of themovable objects.

In some embodiments, the moveable objects comprise multiple beadssuspended in the blood, which rotate and/or change position as the bloodflows. In other embodiments, the moveable objects comprise a wheelcomprising a plurality of radiating spokes, which rotates as the bloodflows across the spokes.

Another challenge is that sometimes it may be necessary to slow or stopthe flow of blood through the shunt temporarily, e.g., to allow moreblood to flow through the carotid artery to the brain of the subject.

To address this challenge, some embodiments of the present inventionequip the shunt with a valve configured to control the rate of flowthrough the entry port or exit port of the shunt. For example, the valvemay comprise a pushable element passing through the wall of theaforementioned flow-indication chamber, along with a spring within theflow-indication chamber, which couples the pushable element to an innerwall of the flow-indication chamber. In its resting state, the springholds the pushable element away from the port, such that blood freelyflows through the port. On the other hand, a pushing force sufficient toovercome the force of the spring may push the pushable element over theport, thereby slowing or stopping the flow of blood.

In other embodiments, the shunt is equipped with a tube constrictorconfigured to constrict the tube carrying the blood to or from the port.The tube constrictor comprises a pair of parallel arms, which are shapedto define respective apertures and respective rows of teeth. The rows ofteeth are configured to interlock with one another at a defaultposition, in which the apertures are aligned with one another, and atone or more other positions, in which the apertures are misaligned byvarying degrees. Thus, while the tube passes through the apertures, thetube may be partially or fully constricted by sliding the arms over oneanother. Subsequently to constricting the tube, to resume regular bloodflow, the rows of teeth may be released from one another such that thearms revert to their default positions.

Apparatus Description

Reference is initially made to FIG. 1 , which is a schematicillustration of an apparatus 20 for shunting blood 22, in accordancewith some embodiments of the present invention. An inset portion 44 ofFIG. 1 shows part of the interior of apparatus 20.

Apparatus 20, which may be referred to as a “shunt,” comprises aflow-indication chamber 24 shaped to define an entry port 26 and an exitport 28. Blood 22 enters flow-indication chamber 24 via entry port 26,flows through the flow-indication chamber, and exits the flow-indicationchamber via exit port 28.

In some embodiments, entry port 26 is configured to couple to an entrytube 30 (or any other entry conduit, such as a catheter) through whichblood 22 flows to apparatus 20. For example, entry tube 30 may befittingly inserted into entry port 26, or the entry port may befittingly inserted into the entry tube.

In some embodiments, apparatus 20 further comprises a filter chamber 32configured to couple to flow-indication chamber 24 and to hold a bloodfilter 34 in filter chamber 32. Blood filter 34 may be secured withinthe filter chamber using any suitable structural components, such as aplurality of ribs 86 as shown in FIG. 3 , which is described below.Filter chamber 32 is shaped to define an entry port 38, through whichblood 22 enters the filter chamber, and an exit port 40, through whichthe blood exits the filter chamber.

As shown in FIG. 1 , the filter chamber may be coupled to theflow-indication chamber downstream from the flow-indication chamber,such that the blood flows through the filter chamber after flowingthrough the flow-indication chamber. (Optionally, a single common portmay function as both exit port 28 and entry port 38.) In suchembodiments, exit port 40 is configured to couple to an exit tube 42 (orany other exit conduit, such as a catheter), which carries the bloodfrom apparatus 20.

Alternatively, the filter chamber may be coupled to the flow-indicationchamber upstream from the flow-indication chamber. (Optionally, a singlecommon port may function as both exit port and entry port 26.) In suchembodiments, entry port 38 of the filter chamber is configured to coupleto entry tube 30, and exit port 28 of the flow-indication chamber isconfigured to couple to exit tube 42.

In some embodiments, apparatus 20 further comprises a threaded ring 36.Flow-indication chamber 24 is configured to screw into one side ofthreaded ring 36, and filter chamber 32 is configured to screw into theother side of the threaded ring such that the two chambers are in fluidcommunication with one another. For example, as shown in FIG. 1 , theflow-indication chamber may be screwed into the upstream side of ring 36and the filter chamber may be screwed into the downstream side of ring36, such that the blood flows directly from exit port 28 into entry port38. Alternatively, the filter chamber may be screwed into the upstreamside of ring 36 and the flow-indication chamber may be screwed into thedownstream side of ring 36, such that the blood flows directly from exitport 40 into entry port 26.

In other embodiments, as shown in FIG. 3 , the flow-indication chamberand filter chamber are coupled to one another via a coupling tube 84.

In yet other embodiments, apparatus 20 does not comprise filter chamber32. In such embodiments, flow-indication chamber 24 may be configured tohold blood filter 34 therein.

Apparatus 20 may shunt blood 22 between any two suitable blood vesselsof a human or animal subject. In other words, apparatus may shunt blood22 from any suitable “source” blood vessel of the subject to anysuitable “sink” blood vessel of the subject. For example, apparatus 20may shunt blood from an artery of the subject to a vein of the subject,with entry tube 30 delivering blood from the artery and exit tube 42carrying the blood to the vein. As a specific example, apparatus 20 mayshunt blood from a carotid artery to a femoral vein during an operationto remove a clot from the carotid artery. Alternatively, apparatus 20may shunt blood from a higher-pressure artery to a lower-pressureartery.

To deploy apparatus 20, the upstream end of entry tube 30 is coupled tothe source blood vessel (e.g., via a stopcock and/or any other suitableequipment), and the downstream end of the entry tube is coupled to theentry port of apparatus 20 (e.g., entry port 26, for embodiments inwhich the flow-indication chamber is upstream from the filter chamber).Similarly, the upstream end of exit tube 42 is coupled to the exit portof apparatus 20 (e.g., exit port 40, for embodiments in which theflow-indication chamber is upstream from the filter chamber), and thedownstream end of the exit tube is coupled to the sink blood vessel(e.g., via a stopcock and/or any other suitable equipment).Subsequently, blood flows from the source blood vessel to the sink bloodvessel via apparatus 20.

Blood-Flow Indicators

Apparatus 20 further comprises one or more moveable objects 46 disposedwithin flow-indication chamber 24 and configured to move in response tothe flowing of blood 22 from entry port 26 to exit port 28. At least aportion of the wall 52 of the flow-indication chamber is transparent soas to expose moveable objects 46 to sight. For example, wall 52 may beentirely transparent, as shown in FIG. 3 (described below).Alternatively, as shown in FIG. 1 , the wall may comprise at least onetransparent window 50. Thus, the physician may readily check the rate ofblood flow through the flow-indication chamber, by observing the degreeof movement of moveable objects 46. In some embodiments, the transparentportion of wall 52 comprises a magnifying lens, configured to magnifymoveable objects 46.

In some embodiments, moveable objects 46 comprise a plurality of beads48, which rotate and/or change position as the blood flows. Typically,beads 48 have a density less than that of blood 22, such that the beadsremain suspended in the blood. Beads 48 may comprise any suitablehemocompatible material such as a metal, plastic, wood, latex, syntheticrubber, or any combination of the above.

In general, each of the beads may have any suitable shape. For example,beads 48 may comprise at least one spherical bead 48 a. Alternatively oradditionally, beads 48 may comprise at least one bead comprisingmultiple faces; such a bead may move more in response to the blood flow,relative to spherical bead 48 a, due to the greater force applied to thebead by the blood. Examples of beads comprising multiple faces include acubical bead 48 b and a pyramidical bead 48 c.

In general, larger beads may be more noticeable than smaller beads;hence, in some embodiments, for each bead 48, the Cartesian distancebetween any two points on the outer surface of the bead is greater than0.1 cm. Alternatively or additionally, for increased movement of thebead, the Cartesian distance between any two points on the outer surfaceof the bead may be less than 0.65 cm.

In some embodiments, each of the beads is coated with an anticoagulant,such as heparin.

In some embodiments, for greater visibility, the color of the beadscontrasts with that of blood 22. Suitable contrasting colors includeblack, blue, and white. Alternatively, the beads may have any othercolor.

In some embodiments, exit port 28 is covered with a filter configured toinhibit any of the beads from passing through. Alternatively oradditionally, as described above, filter chamber 32 may be coupled tothe flow-indication chamber downstream from the flow-indication chamber,such that any beads that pass through exit port 28 are filtered from theblood by filter 34.

Reference is now made to FIG. 2 , which is a schematic illustration ofapparatus 20, in accordance with some embodiments of the presentinvention. An inset portion 58 of FIG. 2 shows part of the interior ofapparatus 20.

In some embodiments, moveable objects 46 comprise a rotational memberconfigured to rotate in response to the blood exerting a force on therotational member.

For example, moveable objects 46 may comprise a wheel 54 comprising aplurality of spokes 56 (which may also be referred to as “radialmembers”) and configured to rotate in response to blood 22 exerting aforce on spokes 56. For noticeability, the length of each spoke 56 maybe greater than 0.6 cm, and/or the width of each spoke may be greaterthan 0.3 cm. Alternatively or additionally, to obviate the need for anoverly large flow-indication chamber, the length of each spoke 56 may beless than 3.8 cm, and/or the width of each spoke may be less than 1.3cm.

Using two dashed lines, inset portion 58 demarcates the unimpeded path60 of the blood, i.e., the path from entry port 26 to exit port 28 thatthe blood would follow in the absence of wheel 54. Typically, wheel 54is positioned relative to the entry and exit ports such that each spoke,when perpendicular to path 60 at any point along the path, intersectsthe path. Thus, the flow of blood through the flow-indication chambergenerally keeps the wheel rotating in a single direction. For example,in FIG. 2 , the wheel rotates clockwise, as indicated by a rotationindicator 55.

For example, denoting the end of the spoke closest to hub 62 as theproximal end of the spoke and the opposite end as the distal end of thespoke, the most proximal point on the spoke that intersects path 60 maybe located between 50% and 80% of the length of the spoke from theproximal end of the spoke. (For example, if the spoke is 3 cm long, themost proximal point on the spoke that intersects path 60 may be locatedbetween 1.5 and 2.4 cm from the proximal end of the spoke.)Advantageously, this positioning of the wheel may increase therotational force to which the wheel is subjected.

In some embodiments, the internal walls 61 of flow-indication chamber 24constrict the space within the chamber in which the blood can flow, suchthat the blood follows path 60 at a greater speed and hence, appliesgreater force to the rotational member.

Typically, as shown in Section A-A, wheel 54 is mounted onto a shaft 64(i.e., shaft 64 passes through hub 62), such that the wheel rotatesabout the shaft. Shaft 64 is coupled at each of its ends to wall 52.

The rotational member (e.g., wheel 54) may be any suitable color,including a color that contrasts with that of blood, as described abovefor beads 48 (FIG. 1 ).

In alternative embodiments, Doppler ultrasound is used to measure therate of blood flow. For example, a fixture, shaped to define a socket,may be fitted over one of the tubes, and a standard Doppler ultrasoundprobe may be inserted into the socket.

Regulating Blood Flow

Reference is again made to FIG. 1 .

In some embodiments, apparatus 20 further comprises a valve 66configured to regulate the flow of blood through the flow-indicationchamber. Thus, using valve 66, a physician may control the rate at whichblood is shunted.

In some embodiments, valve 66 comprises a pushable element 68 passingthrough wall 52 and configured to cover entry port 26 or exit port 28upon being pushed into the flow-indication chamber. Typically, a gasket76 (made of rubber, for example) seals the aperture in wall 52 throughwhich the pushable element passes, such that blood does not leak throughthe wall.

In such embodiments, valve 66 further comprises a spring 78 coupled tothe pushable element (e.g., by virtue of being coupled to a ledge 82coupled to the pushable element) and to an inner wall of theflow-indication chamber (e.g., the inside of wall 52). Spring 78 isconfigured to inhibit the pushable element from covering the entry portor exit port in the absence of any pushing force applied to the pushableelement. Thus, to slow or stop the flow of blood, the physician mustcontinuously exert a pushing force to counteract the force applied bythe spring, such that the physician is unlikely to forget that the flowhas been slowed or stopped.

Typically, as shown in FIG. 1 , spring 78 comprises a tension spring 80.In the absence of any pushing force, spring 80 is maximally compressed,such that the tension spring holds the pushable element in its outermostposition.

In some embodiments, pushable element 68 comprises a neck 70 and a foot72, which protrudes from the end of neck 70 that is inside theflow-indication chamber. As neck 70 is pushed further into theflow-indication chamber, foot 72 covers a greater portion of the entryport or exit port, thereby slowing the flow of blood. Upon the neckbeing maximally pushed, foot 72 completely covers the port, such thatthe flow is stopped. Optionally, the opposite end of neck 70, which isoutside the flow-indication chamber, may terminate at a head 74, whichis wider than the neck and thus facilitates the pushing of the neck intothe flow-indication chamber.

In other embodiments, valve 66 comprises a pullable element passingthrough wall 52 and configured to cover entry port 26 or exit port 28upon being pulled.

(It is noted that valve 66 may also be combined with any other suitableembodiment of moveable objects 46, such as the embodiment of FIG. 2 .)

Reference is now made to FIG. 3 , which is a schematic illustration ofapparatus 20, in accordance with some embodiments of the presentinvention.

In some embodiments, apparatus 20 comprises tube constrictor 88, whichmay also be referred to as a “locking clip.” Tube constrictor 88comprises a first appendage 90 a, shaped to define a first aperture 92a, and a second appendage 90 b, shaped to define a second aperture 92 b.

As further described below with reference to FIGS. 4A-B, tubeconstrictor 88 is configured to control the rate of blood flow through atube passing through apertures 92 a and 92 b by constricting the tubewith varying degrees of constriction. Thus, apparatus 20 need notnecessarily comprise valve 66 (FIG. 1 ).

For example, tube constrictor 88 may provide two degrees ofconstriction: no (0%) constriction, and full (100%) or partial (e.g.,80%-90%) constriction. Alternatively, tube constrictor 88 may providethree or more degrees of constriction. An example of four degrees ofconstriction is 0%, 20%-40% (e.g., 33%), 60%-80% (e.g., 66%), and90%-100%.

(In the context of the present application, including the claims, thetube may be considered to be constricted by x % if the rate of bloodflow through the tube is x % of what the rate would be if the tube werenot constricted at all.)

In some such embodiments, flow-indication chamber 24 is coupled tofilter chamber 32 via coupling tube 84, and tube constrictor 88 isconfigured to constrict the coupling tube. For example, as shown in FIG.3 , first appendage 90 a and second appendage 90 b may protrude fromfilter chamber 32 in the upstream direction, i.e., the first and secondappendages may protrude beyond entry port 38, and coupling tube 84 maycarry blood to entry port 38 through the first and second apertures.Alternatively, the first and second appendages may protrude fromflow-indication chamber 24 in the downstream direction, i.e., the firstand second appendages may protrude beyond exit port 28, and couplingtube 84 may carry blood from exit port 28 through the first and secondapertures.

In other such embodiments, tube constrictor 88 is configured toconstrict entry tube 30. In other words, first appendage 90 a and secondappendage 90 b protrude from flow-indication chamber 24 in the upstreamdirection, i.e., the first and second appendages protrude beyond entryport 26, and entry tube 30 carries blood to entry port 26 through thefirst and second apertures. (In this case, flow-indication chamber 24may be coupled to filter chamber 32 as in FIGS. 1-2 , or filter chamber32 may be omitted.)

In yet other such embodiments, tube constrictor 88 is configured toconstrict exit tube 42. In other words, first appendage 90 a and secondappendage 90 b protrude from filter chamber 32 in the downstreamdirection, i.e., the first and second appendages protrude beyond exitport 40, and exit tube 42 carries blood from exit port 40 through thefirst and second apertures. (In this case, flow-indication chamber 24may be coupled to filter chamber 32 as in FIGS. 1-2 , or flow-indicationchamber 24 may be omitted.)

For those embodiments in which apparatus 20 comprises flow-indicationchamber 24, the flow-indication chamber may contain any suitablemoveable objects 46, such as wheel 54 or beads 48 (FIG. 1 ).

In some embodiments, the first and second appendages are continuous withthe wall of the chamber from which the appendages protrude, i.e., thewall extends beyond the chamber so as to define the appendages. In otherembodiments, the appendages are coupled to the wall of the chamber,e.g., using any suitable adhesive.

Typically, each appendage comprises a back arm 100, which protrudes fromthe chamber, and a front arm 102, which is angled (e.g., atapproximately 90 degrees) with respect to back arm 100 and is shaped todefine the aperture through which the tube passes.

Reference is now made specifically to inset portion 110 of FIG. 3 ,which shows the back of front arm 102 of first appendage 90 a, i.e., thesurface of the front arm that faces second appendage 90 b.

In addition to first aperture 92 a, first appendage 90 a (e.g., frontarm 102 of the first appendage) is shaped to define a first row 94 a ofone or more teeth 96. Similarly, as shown in FIGS. 4A-B, secondappendage 90 b (e.g., front arm 102 of the second appendage) is shapedto define a second row 94 b of one or more teeth 96 parallel to firstrow 94 a. As further described below with reference to FIGS. 4A-B,second row 94 b is configured to interlock with first row 94 a atmultiple different relative positions of the first appendage and secondappendage. In these different positions, second aperture 92 b is alignedwith first aperture 92 a with different respective degrees of alignmentsuch that coupling tube 84 (or any other tube passing through theapertures) is constricted with different respective degrees ofconstriction.

Reference is now made to FIGS. 4A-B, which are schematic illustrationsof tube constrictor 88, in accordance with some embodiments of thepresent invention.

In FIG. 4A, the first and second appendages are at a first relativeposition in which second aperture 92 b is aligned with first aperture 92a, such that coupling tube 84 is not constricted. Subsequently, one orboth of the appendages may be shifted such that the appendages assume asecond relative position in which the two apertures are less alignedwith one another, and hence tube 84 is mostly constricted, as shown inFIG. 4B.

In some embodiments, as shown in FIGS. 4A-B, each tooth 96 is angledbackward (e.g., toward back arm 100 of the appendage), such that thetooth comprises a longer front edge 104 and a shorter back edge 106. Insuch embodiments, the tube may be constricted by advancing the two rowsof teeth relative to one another, e.g., by pushing at least one frontarm 102 toward the back arm 100 of the other appendage. For example, asindicated in FIG. 4A by pinch indicators 98, the appendages may bepinched together, e.g., using a forefinger placed on one back arm 100and a thumb placed on the other back arm. As one or both of the rows areadvanced, front edges 104 slide across each other, until the rows ofteeth interlock at the next position by virtue of the contact betweenback edges 106, which inhibits the rows from sliding backward.

In other embodiments, each tooth 96 is angled forward, toward the tip ofthe appendage. In such embodiments, the tube may be constricted bymoving at least one row of teeth backward relative to the other row ofteeth, e.g., by pulling at least one front arm 102 away from the backarm 100 of the other appendage.

In some embodiments, the first and second appendages are configured torevert to a default relative position, in which the tube is notconstricted, upon a release of first row 94 a and second row 94 b fromone another, as indicated in FIG. 4B by release indicators 108. In otherwords, at least one of the appendages is elastic, such that any movementfrom the default relative position causes the appendage to store elasticenergy that, upon release of the rows from one another, causes theappendage to revert to the default position. Alternatively oradditionally, upon release, the first and second appendages may revertto their default relative position due to elastic energy stored in thewall of the tube while the tube is constricted.

(It is emphasized that the appendages may be shaped to define fewerteeth than are shown in the figures. For example, one appendage may beshaped to define a single tooth, and the other appendage may be shapedto define N 2 teeth, such that N degrees of constriction are provided.)

Typically, the tube is not completely constricted in any of thepositions in which the rows of teeth interlock with one another. Inother words, as shown in FIG. 4B, even at the most constrictedinterlocked position, the tube may remain partly (e.g., 10%-20%)unconstricted. Thus, advantageously, full constriction of the tuberequires that the physician continuously apply a force to one or both ofthe appendages, such that the physician is unlikely to forget that theflow has been stopped. For example, in the scenario shown in FIG. 4B,full constriction of the tube may require a continuous pinching of theappendages. In the absence of a pinching force, the elastic energystored in the appendages and/or the wall of the tube causes theappendages to revert to the most constricted interlocked position.

(For embodiments in which the teeth are angled backward, the mostconstricted interlocked position is that in which the frontmost tooth ofone appendage locks against the backmost tooth of the other appendage.For embodiments in which the teeth are angled forward, the mostconstricted interlocked position is that in which the frontmost tooth ofone appendage locks against the frontmost tooth of the other appendage.)

Alternatively to tube constrictor 88, apparatus 20 may comprise anyother clamp that protrudes from one of the chambers and is configured toconstrict a tube in fluid communication with the chamber. The clamp maybe continuous with the wall of the chamber from which the clampprotrudes, or coupled to the wall of the chamber.

It will be appreciated by persons skilled in the art that the presentinvention is not limited to what has been particularly shown anddescribed hereinabove. Rather, the scope of embodiments of the presentinvention includes both combinations and subcombinations of the variousfeatures described hereinabove, as well as variations and modificationsthereof that are not in the prior art, which would occur to personsskilled in the art upon reading the foregoing description. Documentsincorporated by reference in the present patent application are to beconsidered an integral part of the application except that to the extentany terms are defined in these incorporated documents in a manner thatconflicts with the definitions made explicitly or implicitly in thepresent specification, only the definitions in the present specificationshould be considered.

1. Apparatus for shunting blood, the apparatus comprising: aflow-indication chamber shaped to define an entry port and an exit port;and one or more moveable objects disposed within the flow-indicationchamber and configured to move in response to a flowing of the bloodfrom the entry port to the exit port, at least a portion of a wall ofthe flow-indication chamber being transparent so as to expose themoveable objects to sight.
 2. The apparatus according to claim 1,wherein the moveable objects comprise a plurality of beads.
 3. Theapparatus according to claim 2, wherein at least one of the beadscomprises multiple faces.
 4. The apparatus according to claim 2, whereineach of the beads is coated with an anticoagulant.
 5. The apparatusaccording to claim 1, wherein the moveable objects comprise a rotationalmember configured to rotate in response to the blood exerting a force onthe rotational member.
 6. The apparatus according to claim 5, whereinthe rotational member comprises a wheel comprising a plurality ofspokes.
 7. The apparatus according to claim 6, wherein the wheel ispositioned relative to the entry port and exit port such that each ofthe spokes, when perpendicular to an unimpeded path of the blood fromthe entry port to the exit port, intersects the unimpeded path.
 8. Theapparatus according to claim 7, wherein a most proximal point on each ofthe spokes that intersects the unimpeded path is located between 50% and80% of a length of the spoke from a proximal end of the spoke.
 9. Theapparatus according to claim 1, further comprising a filter chamberconfigured to couple to the flow-indication chamber and to hold a bloodfilter in the filter chamber.
 10. The apparatus according to claim 9,further comprising a threaded ring, wherein the filter chamber is shapedto define a filter-chamber port, wherein the flow-indication chamber isconfigured to screw into a first side of the threaded ring, and whereinthe filter chamber is configured to screw into a second side of thethreaded ring such that the entry port or exit port is fluidly connectedwith the filter-chamber port.
 11. The apparatus according to claim 1,wherein the flow-indication chamber is further configured to hold ablood filter therein.
 12. The apparatus according to claim 1, furthercomprising a valve configured to regulate the flowing of the bloodthrough a port selected from the group of ports consisting of: the entryport, and the exit port.
 13. The apparatus according to claim 12,wherein the valve comprises: a pushable element passing through a wallof the flow-indication chamber and configured to cover the port uponbeing pushed into the flow-indication chamber; and a spring coupled tothe pushable element and to an inner wall of the flow-indicationchamber, and configured to inhibit the pushable element from coveringthe port in an absence of any pushing force applied to the pushableelement.
 14. The apparatus according to claim 13, wherein the springcomprises a tension spring.
 15. A method, comprising: coupling anupstream end of a first conduit to a source blood vessel of a subjectand a downstream end of the first conduit to an entry port of a shunt;and coupling an upstream end of a second conduit to an exit port of theshunt and a downstream end of the second conduit to a sink blood vesselof the subject, such that blood flows from the source blood vessel tothe sink blood vessel via the shunt, thus causing movement of one ormore moveable objects disposed within the shunt, the movement beingvisible through a wall of the shunt.
 16. The method according to claim15, wherein the moveable objects include a plurality of beads.
 17. Themethod according to claim 15, wherein the movable objects include arotational member that rotates in response to the blood exerting a forceon the rotational member.
 18. The method according to claim 17, whereinthe rotational member includes a wheel including a plurality of spokes.19. The method according to claim 15, wherein the shunt includes aflow-indication chamber, which contains the moveable objects, and afilter chamber, which is coupled to the flow-indication chamber andholds a blood filter in the filter chamber.
 20. The method according toclaim 15, further comprising, using a valve, regulating the flow of theblood through the shunt.